Selected Publications

Computational approaches to the prediction of blood-brain barrier permeability: A comparative analysis of central nervous system drugs versus secretase inhibitors for Alzheimer’s disease. Gilbert M. Rishton, Kristen LaBonte, Antony J. Williams, Karim Kassam, Eduard Kolovanov: Current Opinion in Drug Discovery & Drug Development (2006) 9(3):303-313. 

Failure and Success in Modern Drug Discovery: Guiding Principles in the Establishment of High Probability of Success Drug Discovery Organizations. Gilbert M. Rishton: Medicinal Chemistry (2005) 1(5), 519-527. 

Fenchylamine Sulfonamide Inhibitors of Amyloid β Production by the γ-Secretase Proteolytic Pathway: Potential Small Molecule Therapeutic Agents for the Treatment of Alzheimer’s Disease. Gilbert M. Rishton, Daniel M. Retz, Paul A. Tempest, James Novotny, Steve Kahn, James J. S. Treanor, Jack D. Lile, and Martin Citron: Journal of Medicinal Chemistry (2000) 43(12), 2297-2299. 

Reactive Compounds and in vitro False Positives in HTS. Gilbert M. Rishton (Invited Editorial): Drug Discovery Today (1997) 2(9) 382-384. 

Nonleadlikeness and Leadlikeness in Biochemical Screening. Gilbert M. Rishton (Invited Review): Drug Discovery Today (2003) 8(2) 86-96. 

Selected Presentations

Chemically Conditioned Extracts of Ginger Oil: Leadlike “Alkaloidal” Compounds Derived from Natural Extracts via Reductive Amination. Hiromi Arai, Kristin Beierle, Cody Fullenwider, Zoya Kai, Gilbert M. Rishton: Poster presentation for American Chemical Society Western Regional Meeting (January 22-25, 2006) Anaheim, CA. 

Chemically Conditioned Extracts of Ginger Oil: Leadlike “Alkaloidal” Compounds Derived from Natural Extracts via Reductive Amination. Hiromi Arai, Kristin Beierle, Cody Fullenwider, Zoya Kai, Gilbert M. Rishton: Poster presentation for 18 th Annual Biotechnology Symposium: The Brain and the Future (January 13-15, 2006) San Jose, CA. 

Chemically Conditioned Extracts of Ginger Oil: Leadlike Compounds Derived from Natural Extracts for Biochemical Screening. Hiromi Arai, Zoya Kai, Gilbert M. Rishton: Poster presentation for Annual Biomedical Research Conference for Minority Students (November 2-5, 2005) Atlanta, GA. 

Nonleadlikeness, Leadlikeness, and Target Tractability in Small Molecule Drug Discovery. Gilbert M. Rishton: Oral presentation for Molecules that Matter: Case Studies in Medicinal Chemistry. (April 12, 2005) Berlin, Germany.